DANILO MARIMPIETRI

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Here, a new two-component hydrogel (CP1OP2-Hgel) was developed, simply by dispersing in water two cationic bactericidal polymers (CP1 and OP2) effective against several multidrug-resistant (MDR) clinical isolates of the most relevant Gram-positive and Gram-negative species. Interestingly, while OP2 acts only as an antibacterial ingredient when...

Fenretinide (N-(4-hydroxyphenyl)-retinamide, 4-HPR) is a synthetic retinoid with fewer adverse effects than natural retinoids, whose efficacy against ovarian, prostate, small cell lung, brain, neuroectodermal-derived tumors has been widely demonstrated in several in vitro and preclinical studies. Unfortunately, clinical responses both in adult...

Fenretinide (4-HPR), a synthetic retinoid with low toxicological profile, is endowed with high an-titumor activity. However, 4-HPR shows poor oral absorption due to its low solubility, and variable blood concentrations for a massive hepatic first pass effect. Here, we prepared nanoparticles (NPs) made of 4-ammoniunbutylstyrene random copolymer...

Children affected by chronic liver disease exhibit impaired neurocognitive development and growth due to the low absorption and digestion of nutrients. Furthermore, malnutrition is an adverse prognostic factor in liver transplantation as it is associated with an increase in morbidity and mortality....

Liposomal amphotericin B (Ambisome®) is the gold standard for the treatment and prevention of fungal infections both in the adult and pediatric populations. The lyophilized dosage form has to be reconstituted and diluted by hospital staff, but its management can be challenging due to the spontaneous tendency of amphotericin B to form aggregates...

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