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DAS , Indrajit

Last name: DAS

First name: Indrajit

October 2020 (v1)

Journal article

Metadata-only

Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

Weulersse, Marianne Asrir, Assia Pichler, Andrea

CD8+ T cells within the tumor microenvironment (TME) are exposed to various signals that ultimately determine functional outcomes. Here, we examined the role of the co-activating receptor CD226 (DNAM-1) in CD8+ T cell function. The absence of CD226 expression identified a subset of dysfunctional CD8+ T cells present in peripheral blood of...

Uploaded on: December 4, 2022