DE ROSA S.

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Metabolic endotoxemia is a systemic condition in which increased plasma lipopolysaccharide (LPS) levels induced by infections may lead to chronic inflammation-related diseases and hyperinflammation. Microbiota is considered the primary source of endotoxins and LPS. Critically ill patients, highly susceptible to metabolic and inflammatory...

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Organ crosstalk is a complex biological communication between distal organs mediated via cellular, soluble, and neurohormonal actions, based on a two-way pathway. The communication between the central nervous system and peripheral organs involves nerves, endocrine, and immunity systems as well as the emotional and cognitive centers of the...

Acute critical illnesses can alter vital functions with profound biological, biochemical, metabolic, and functional modifications. Despite etiology, patient's nutritional status is pivotal to guide metabolic support. The assessment of nutritional status remains complex and not completely elucidated. Loss of lean body mass is a clear marker of...

In critical care medicine, where there is a demanding career with a problematic work-life balance, mentoring is an important support tool to grow professionally, creating a network of support throughout the career. The mentoring process consists of evidence-based steps to guide critical care mentors and mentees and pair them with each other...