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DELGADO CORTÉS , M.j.

Last name: DELGADO CORTÉS

First name: M.j.

May 24, 2016 (v1)

Publication

Metadata-only

Inflammatory animal model for parkinson's disease: the intranigral injection of LPS induced the inflammatory process along with the selective degeneration of nigrostriatal dopaminergic neurons

Machado Quintana, Alberto Herrera Carmona, Antonio José Venero Recio, José Luis

We have developed an animal model of degeneration of the nigrostriatal dopaminergic neurons, the neuronal system involved in Parkinson's disease (PD). The implication of neuroinflammat ion on this disease was originally established in 1988, when the presence of activated microglia in the substantia nigra (SN) of parkinsonians was reported by...

Uploaded on: December 4, 2022
May 25, 2016 (v1)

Publication

Metadata-only

Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: Possible implication in parkinson's disease incidence

Machado Quintana, Alberto Herrera Carmona, Antonio José Venero Recio, José Luis

Inflammatory processes described in Parkinson's disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation enhances the degeneration of the nigrostriatal dopaminergic system induced by different insults; different peripheral...

Uploaded on: March 27, 2023