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DELIGIA , Francesco

Last name: DELIGIA

First name: Francesco

2018 (v1)

Publication

Metadata-only

Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1receptor ligand antagonists

Murineddu, Gabriele Deligia, Francesco Ragusa, Giulio

A series of sulfenamide and sulfonamide derivatives was synthesized and evaluated for the affinity at CB1and CB2receptors. The N-bornyl-S-(5,6-di-p-tolylpyridazin-3-yl)-sulfenamide, compound 11, displayed good affinity and high selectivity for CB1receptors (Kivalues of 44.6 nM for CB1receptors and >40 μM for CB2receptors, respectively). The...

Uploaded on: April 14, 2023