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DELSO , Ignacio

Last name: DELSO

First name: Ignacio

April 7, 2021 (v1)

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Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity

Latorre Muro, Pedro Baeza, Josue Hurtado Guerrero, Ramón

Acetylation is known to regulate the activity of cytosolic phosphoenolpyruvate carboxykinase (PCK1), a key enzyme in gluconeogenesis, by promoting the reverse reaction of the enzyme (converting phosphoenolpyruvate to oxaloacetate). It is also known that the histone acetyltransferase p300 can induce PCK1 acetylation in cells, but whether that is...

Uploaded on: December 4, 2022
April 6, 2021 (v1)

Publication

Metadata-only

Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter

Furze, Christopher M. Delso, Ignacio Casal, Enriqueta

The Mycobacterium tuberculosis (Mtb) LpqY-SugABC ATPbinding cassette transporter is a recycling system that imports trehalose released during remodeling of the Mtb cell-envelope. As this process is essential for the virulence of the Mtb pathogen, it may represent an important target for tuberculosis drug and diagnostic development, but the...

Uploaded on: December 4, 2022