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DENORA NUNZIO

Last name: DENORA NUNZIO

2015 (v1)

Publication

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Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and beta-Amyloid (Abeta) Aggregation

TONELLI, MICHELE Catto Marco* TASSO, BRUNO

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Uploaded on: April 14, 2023
2018 (v1)

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Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain

Franchini Silvia Bencheva Ivanova Leda Battisti Umberto Maria

AIM: Targeting 5-HT1A receptor (5-HT1AR) as a strategy for CNS disorders and pain control. METHODOLOGY: A series of 1,3-dioxolane-based 2-heteroaryl-phenoxyethylamines was synthesized by a convergent approach and evaluated at α1-adrenoceptors and 5-HT1AR by binding and functional experiments. Absorption, distribution, metabolism, excretion and...

Uploaded on: April 14, 2023