D

S

DEPIL , Stéphane

Last name: DEPIL

First name: Stéphane

April 2012 (v1)

Journal article

Metadata-only

EBV Latency II-derived Peptides Induce A Specific CD4+ Cytotoxic T-cell Activity and Not A CD4+ Regulatory T-cell Response

Moralès, Olivier Depil, Stéphane Mrizak, Dhafer

Epstein-Barr virus (EBV) is associated with several malignant diseases that can be distinguished by their patterns of viral latent gene expression. We developed here an original peptidic approach to favor the induction of a specific CD4+ T-cell response against EBV latency II malignancies (Hodgkin's lymphoma, nasopharyngeal carcinoma, T/NK...

Uploaded on: December 4, 2022
February 21, 2024 (v1)

Publication

Metadata-only

Targeting Heterochromatin Eliminates Malignant Hematopoietic Stem and Progenitor Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways

Hidaoui, Donia Chelbie, Rabie Bohm, Mathieu

Abstract Chronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy affecting the elderly, for which therapeutic options are limited. DNA hypomethylating agents (HMAs) provide transient responses, failing to eradicate the malignant clone. Hematopoietic stem cell (HSC) aging involves a reorganization of heterochromatin, evidenced by...

Uploaded on: February 23, 2024