DERIJARD , Benoit

Kv channels represent new important targets for the control of cancer growth and a better understanding of their regulating pathways in cancer cells is necessary to develop therapeutic strategies. In this study, we have addressed the putative modulation of Kv by MAP kinases through a pharmacological approach. We have found that the commonly...

A significant challenge in MPA management is the necessity for a bottom-up approach that aligns with the needs of the majority of stakeholders.FishMPABlue2 is a European Interreg Med project through which 11 pilot Marine Protected Areas from 6 Mediterranean countries were able to test 13 management-related measures (Governance toolkit) to...

International audience

International audience

Demonstrations of both pro-apoptotic and pro-survival abilities of Fas (TNFRSF6/CD95/APO-1) have led to a shift from the exclusive ``Fas apoptosis'' to ``Fas multisignals'' paradigm and the acceptance that Fas-related therapies face a major challenge, as it remains unclear what determines the mode of Fas signaling. Through protein evolution...

The peroxisome proliferator–activated receptor γ (PPARγ) is highly expressed in the colon mucosa and its activation has been reported to protect against colitis. We studied the involvement of PPARγ and its heterodimeric partner, the retinoid X receptor (RXR) in intestinal inflammatory responses. PPARγ1/− and RXRα1/− mice both displayed a...

Marine noise is an emerging pollutant inducing a variety of negative impacts on many animal taxa, including fish. Fish population persistence and dynamics rely on the supply of early life stages, which are often very sensitive to disturbance. Impacts of marine noise pollution (MNP) on juvenile fish have rarely been investigated in temperate...