DHIB , Haroun

WTX/AMER1 is an important developmental regulator, mutations in which have been identified in a proportion of patients suffering from the renal neoplasm Wilms' tumor and in the bone malformation syndrome Osteopathia Striata with Cranial Sclerosis (OSCS). Its cellular functions appear complex and the protein can be found at the membrane, within...

Congenital abnormalities of the kidney and the urinary tract (CAKUT) belong to the most common birth defectsin human, but the molecular basis for the majority of CAKUT patients remains unknown. Here we show thatthe transcription factor SOX11 is a crucial regulator of kidney development. SOX11 is expressed in bothmesenchymal and epithelial...