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DINANT , Christoffel

Last name: DINANT

First name: Christoffel

October 4, 2022 (v1)

Publication

Metadata-only

CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway

Gómez Cabello, Daniel Pappas, George Aguilar Morante, Diana

The RNA world is changing our views about sensing and resolution of DNA damage. Here, we develop single-molecule DNA/RNA analysis approaches to visualize how nascent RNA facilitates the repair of DNA double-strand breaks (DSBs). RNA polymerase II (RNAPII) is crucial for DSB resolution in human cells. DSB-flanking, RNAPII-generated nascent RNA...

Uploaded on: December 5, 2022