El objetivo general de este proyecto es comparar la actividad de cotrimoxazol, vancomicina, linezolid y cloxacilina utilizados en monoterapia, en un modelo discriminativo de neumonía experimental causada por cespas de Staphylococcus aureus sensible a meticilina (SASM) y Staphylococcus aureus resitente a meticilina (SARM). Igualmente, evaluar la...
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April 16, 2015 (v1)PublicationUploaded on: March 26, 2023
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March 28, 2022 (v1)Publication
Background Suppression of SOS response and overproduction of reactive oxygen species (ROS) through detoxification system suppression enhance the activity of fluoroquinolones. Objectives To evaluate the role of both systems in the evolution of resistance to ciprofloxacin in an isogenic model of Escherichia coli. Methods Single-gene deletion...
Uploaded on: March 25, 2023 -
January 10, 2023 (v1)Publication
Antimicrobial resistance (particularly through extended-spectrum β-lactamase and aminoglycoside-modifying enzyme production) in neonatal sepsis is a global problem, particularly in low- and middle-income countries, with significant mortality rates. High rates of resistance are reported for the current WHO-recommended first-line antibiotic...
Uploaded on: March 24, 2023 -
November 22, 2017 (v1)Publication
Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal...
Uploaded on: December 4, 2022 -
October 23, 2017 (v1)Publication
Suppression of the SOS response has been postulated as a therapeutic strategy for potentiating antimicrobial agents. We aimed to evaluate the impact of its suppression on reversing resistance using a model of isogenic strains of Escherichia coli representing multiple levels of quinolone resistance. E. coli mutants exhibiting a spectrum of SOS...
Uploaded on: December 4, 2022 -
May 10, 2021 (v1)Publication
Adhesion is an initial and important step in Acinetobacter baumannii causing infections. However, the exact molecular mechanism of such a step between A. baumannii and the host cells remains unclear. Here, we demonstrated that the phosphorylcholine (ChoP)-containing outer membrane protein of A. baumannii binds to A549 cells through...
Uploaded on: December 4, 2022 -
July 25, 2017 (v1)Publication
The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli strains that have different fosfomycin MICs. Our methods included the use of a hollow fiber infection model with three clinical ESBL-producing E....
Uploaded on: March 26, 2023 -
October 21, 2021 (v1)Publication
Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly reported. LLFR strains can become clinically resistant under urinary tract physiological conditions or may act as gateways for highly resistant subpopulations by the selection of additional LLFR mutations. Nevertheless,...
Uploaded on: March 25, 2023