En esta tesis doctoral hemos afrontado el estudio de mecanismos implicados en el mantenimiento de la proteostasis en dos tipos diferentes de células del sistema nervioso: microglía y neuronas. Para ello, se ha usado un modelo de estrés proteotóxico basado en la acumulación de proteínas tras el bloqueo del proteasoma con MG132, un inhibidor...
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May 17, 2022 (v1)PublicationUploaded on: December 4, 2022
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September 20, 2017 (v1)Publication
Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that neuroinflammation alters cellular proteostasis through immunoproteasome induction, leading to a transient decrease of proteasome activity. Here, we further investigated the role of acute lipopolysaccharide (LPS)-induced hippocampal...
Uploaded on: March 27, 2023 -
June 10, 2019 (v1)Publication
Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) injury. SIRT2 has been suggested to exert effects opposite those of SIRT1; however, its roles in neurodegeneration and neuron...
Uploaded on: March 27, 2023 -
April 16, 2021 (v1)Publication
Diabetes and metabolic syndrome are associated with the typical American high glycemia diet and result in accumulation of high levels of advanced glycation end products (AGEs), particularly upon aging. AGEs form when sugars or their metabolites react with proteins. Associated with a myriad of age-related diseases, AGEs accumulate in many...
Uploaded on: March 27, 2023