D

L

DOUGUET , Laetitia

Last name: DOUGUET

First name: Laetitia

Institution: UCA

Links

June 2019 (v1)

Journal article

Metadata-only

Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?

Benzaquen, Jonathan Heeke, Simon Janho Dit Hreich, Séréna

International audience

Uploaded on: December 4, 2022
December 2021 (v1)

Journal article

Metadata-only

A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

Douguet, Laetitia Janho Dit Hreich, Serena Benzaquen, Jonathan

Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve patient outcome. We develop a chemical positive modulator (HEI3090) of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the growth of lung...

Uploaded on: December 4, 2022
January 28, 2021 (v1)

Journal article

Metadata-only

A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

Douguet, Laetitia Janho Dit Hreich, Serena Benzaquen, Jonathan

Abstract Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve patient outcome. We develop a chemical positive modulator (HEI3090) of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the...

Uploaded on: January 22, 2024