DOYEN , Denis

The NHE1 Na[+]/H[+] exchanger plays a key role in regulating pH and intracellular volume. Its role is paradoxical during ischemia-reperfusion where its activation causes an overload in sodium and indirectly in calcium which can cause disorders during reperfusion, particularly in excitable tissues such as the heart. This exchanger is regulated...

Na + /H + exchangers are membrane transporters conserved in all living systems and therefore are assumed to be amongst the most ancestral molecular devices that equipped the first protocells. Following the cloning and sequencing of its gene, the mammalian NHE1, that regulates pH and volume in all cells, has been thoroughly scrutinized by...