DUMONT , Adélie

Abstract Metastatic breast cancer cannot be cured, and alteration of fatty acid metabolism contributes to tumor progression and metastasis. Here, we were interested in the elongation of very long-chain fatty acids protein 5 (Elovl5) in breast cancer. We observed that breast cancer tumors had a lower expression of Elovl5 than normal breast...

International audience

Macrophages rely on tightly integrated metabolic rewiring to clear dying neighboring cells by efferocytosis during homeostasis and disease. Here we reveal that glutaminase-1-mediated glutaminolysis is critical to promote apoptotic cell clearance by macrophages during homeostasis in mice. In addition, impaired macrophage glutaminolysis...

International audience

International audience

International audience

Highlights d Adrenal glands contain multiple macrophage populations d Macrophage sex dimorphism depends on the presence of the cortical X zone d Embryonic and monocyte-derived macrophages co-exist in adrenal glands