This is an Open Access article under the CC BY license.
-
February 13, 2003 (v1)Journal articleUploaded on: December 3, 2022
-
February 13, 2003 (v1)Journal article
This is an Open Access article under the CC BY license.
Uploaded on: February 22, 2023 -
2003 (v1)Journal article
The mechanism by which hypoxia induces gene transcription involves the inhibition of hypoxia-inducible factor (HIF)-1α prolyl hydroxylase activity, which prevents von Hippel-Lindau (vHL)-dependent targeting of HIF-1α to the ubiquitin-proteasome pathway. HIF-1α is stabilized, translocates to the nucleus, interacts with hypoxia-responsive...
Uploaded on: December 4, 2022 -
January 15, 2019 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
September 26, 2003 (v1)Journal article
The mechanism by which hypoxia induces gene transcription is now well established. Hypoxia reduces activity of prolyl hydroxylases (PHD) that hydroxylate specific proline residues in the oxygen-dependent degradation domain (ODD) of hypoxia-inducible factor-1α (HIF-1α). As a consequence, HIF-1α accumulates and promotes hypoxic tolerance by...
Uploaded on: December 3, 2022 -
December 23, 2005 (v1)Journal article
The mechanism by which hypoxia induces gene transcription involves the inhibition of HIF-1α (hypoxia-inducible factor-1 α subunit) PHD (prolyl hydroxylase) activity, which prevents the VHL (von Hippel-Lindau)-dependent targeting of HIF-1α to the ubiquitin/proteasome pathway. HIF-1α thus accumulates and promotes gene transcription. In the...
Uploaded on: December 3, 2022 -
January 15, 2006 (v1)Journal article
The mechanism by which hypoxia induces gene transcription involves the inhibition of HIF-1alpha (hypoxia-inducible factor-1 alpha subunit) PHD (prolyl hydroxylase) activity, which prevents the VHL (von Hippel-Lindau)-dependent targeting of HIF-1alpha to the ubiquitin/proteasome pathway. HIF-1alpha thus accumulates and promotes gene...
Uploaded on: December 4, 2022 -
July 13, 2012 (v1)Journal article
Anatomical lesions in Alzheimer disease-affected brains mainly consist of senile plaques, inflammation stigmata, and oxidative stress. The nuclear factor-κB (NF-κB) is a stress-activated transcription factor that is activated around senile plaques. We have assessed whether NF-κB could be differentially regulated at physiological or...
Uploaded on: December 3, 2022 -
May 12, 2020 (v1)Journal article
Brains that are affected by Alzheimer's disease (AD) are characterized by the overload of extracellular amyloid β (Aβ) peptides, but recent data from cellular and animal models propose that Aβ deposition is preceded by intraneuronal accumulation of the direct precursor of Aβ, C99. These studies indicate that C99 accumulation firstly occurs...
Uploaded on: December 4, 2022 -
May 25, 2018 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
2021 (v1)Journal article
Parkin (PK) is an E3-ligase harboring tumor suppressor properties that has been associated to various cancer types including glioblastoma (GBM). However, PK is also a transcription factor (TF), the contribution of which to GBM etiology remains to be established. Methods: The impact of PK on GBM cells proliferation was analyzed by real-time...
Uploaded on: December 3, 2022 -
April 2023 (v1)Journal article
Abstract The processing of the amyloid precursor protein (APP) is one of the key events contributing to Alzheimer's disease (AD) etiology. Canonical cleavages by β- and γ-secretases lead to Aβ production which accumulate in amyloid plaques. Recently, the matrix metalloprotease MT5-MMP, referred to as η-secretase, has been identified as a novel...
Uploaded on: November 25, 2023 -
November 29, 2022 (v1)Journal article
Abstract The processing of the amyloid precursor protein (APP) is one of the key events contributing to Alzheimer's disease (AD) etiology. Canonical cleavages by β- and γ-secretases lead to Aβ production which accumulate in amyloid plaques. Recently, the matrix metalloprotease MT5-MMP, referred to as η-secretase, has been identified as a novel...
Uploaded on: September 5, 2023 -
August 2011 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
May 17, 2011 (v1)Journal article
The α-secretases A Disintegrin And Metalloprotease 10 (ADAM10) and ADAM17 trigger constitutive and regulated processing of the cellular prion protein (PrPc) yielding N1 fragment. The latter depends on protein kinase C (PKC)-coupled M1/M3 muscarinic receptors activation and subsequent phosphorylation of ADAM17 on its intracytoplasmic threonine...
Uploaded on: December 3, 2022 -
2013 (v1)Journal article
International audience
Uploaded on: December 2, 2022 -
2013 (v1)Journal article
International audience
Uploaded on: October 11, 2023