DURAND-ZALESKI , Isabelle

International audience

The growing incidence of cancer associated with an aging population implies important health challenges that require questioning on the care management of older adults with cancer. There is a need to rethink the care management of older cancer patients with patient-centered decisions and an adjustment of the care pathway for this population....

International audience

The growing incidence of cancer associated with an aging population implies major challenges for the care management of older adults with cancer. Several studies reported age as a limiting factor for access to cancer treatment, with older adults being less likely than younger patients to undergo surgery or receive anticancer drugs or radiation...

Importance Therapeutic options for severe emphysema are limited. Lung volume reduction using nitinol coils is a bronchoscopic intervention inducing regional parenchymal volume reduction and restoring lung recoil.Objective To evaluate the efficacy, safety, cost, and cost-effectiveness of nitinol coils in treatment of severe emphysema.Design,...

Importance: The optimal transfusion strategy in patients with acute myocardial infarction and anemia is unclear.Objective: To determine whether a restrictive transfusion strategy would be clinically noninferior to a liberal strategy.Design, setting, and participants: Open-label, noninferiority, randomized trial conducted in 35 hospitals in...

PURPOSE: Rapid advances in the understanding of cancer biology have transformed drug development thus leading to the approval of targeted therapies and to the development of molecular tests to select patients that will respond to treatments. KRAS status has emerged as a negative predictor of clinical benefit from anti-EGFR antibodies in...