DUTOIT , Valérie

Glioblastoma is an aggressive brain tumor characterized by its high propensity for local invasion, formation of secondary foci within the brain, as well as areas of necrosis. This study aims to (i) provide a technical approach to reproduce features of the disease in vitro and (ii) characterize the tumor/host brain tissue interaction at the...

While molecular subtypes of glioblastoma (GBM) are defined using gene expression and mutation profiles,we identify a unique subpopulation based on addiction to the high-affinity glucose transporter, Glut3.Although Glut3 is a known driver of a cancer stem cell phenotype, direct targeting is complicated by itsexpression in neurons. Using...