EDWARDS , Roderick

The oscillator made of a negative loop of two genes is one of the most classical motifs of genetic networks. We give solutions to control such an oscillator by modifying the synthesis rates. Our models are given by piecewise affine systems, and the control is qualitative, taking only two values. Thus, the necessary measurements for implementing...

Chaotic dynamics have been observed in example piecewise-affine models of gene regulatory networks. Here we show how the underlying Poincaré maps can be explicitly constructed. To do this, we proceed in two steps. First, we consider a limit case, where some parameters tend to ∞, and then consider the case with finite parameters as a...