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EL KHAMISY , Sherif F.

Last name: EL KHAMISY

First name: Sherif F.

September 19, 2017 (v1)

Publication

Metadata-only

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

Zeng, Zhihong Cortés Ledesma, Felipe El Khamisy, Sherif F.

Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5′-phosphotyrosyl bond. Although these intermediates are normally transient, they can be stabilized by antitumor agents that act as Top2 "poisons," resulting in the induction of cytotoxic double-strand...

Uploaded on: December 2, 2022
November 22, 2017 (v1)

Publication

Metadata-only

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage

Zeng, Zhihong Cortés Ledesma, Felipe El Khamisy, Sherif F.

Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand break via a 5′-phosphotyrosyl bond. Although these intermediates are normally transient, they can be stabilized by antitumor agents that act as Top2 "poisons," resulting in the induction of cytotoxic double-strand...

Uploaded on: December 4, 2022