ELEONORA RUSSO

Fenretinide (N-(4-hydroxyphenyl)-retinamide, 4-HPR) is a synthetic retinoid with fewer adverse effects than natural retinoids, effective against ovarian, prostate, small cell lung, brain, neuroectodermal-derived tumors. Clinical responses in adult and pediatric patients are often partial, revealing a limited activity of 4-HPR against existing...

Organogels are semi-solid systems in which a three-dimensional network, composed by the organgelator fibers, immobilizes an organic liquid phase by twisting around it. They find application in different industrial fields as "soft" materials; their mechanical and chemical properties, together with their rheological behavior, make them excellent...

Olive mill wastewater (OMW), derived from olive oil production, has the potential to be transformed, thanks to various handling protocols, from a waste product with environmental concerns into a wealthy product. In fact, OMW is rich in polyphenols and other natural antioxidants, which play a vital role in human health through the regulation of...

Retinoblastoma is a rare, sometimes hereditary, pediatric cancer. In high-income countries this disease has a survival rate approaching 100%, while in low- and middle-income countries the prognosis is fatal for about 80% of cases. Depending on the stage of the disease, different therapeutic protocols are applied. In more advanced forms of the...

Nanotechnology is an important application in modern cancer therapy. In comparison with conventional drug formulations, nanoparticles ensure better penetration into the tumor mass by exploiting the enhanced permeability and retention effect, longer blood circulation times by a reduced renal excretion and a decrease in side effects and drug...

The aim of this work was the development of polymeric films from polysaccharides, containing olive mill wastewater (OMW) as antibacterial agent [1], for skin injures and wound healing. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, it should also maintain a wet medium at the wound interfacing and be easily removed...

Here, to develop new topical antibacterial formulations to treat staphylococcal infections, two pyrazoles (3c and 4b) previously reported as antibacterial agents, especially against staphylococci, were formulated as hydrogels (R1-HG-3c and R1HG-4b) using a cationic polystyrene-based resin (R1) and here synthetized and characterized as gelling...

In order to achieve disease-modifying therapies for the treatment of Alzheimer's disease (AD), the well-known multitarget directed ligands (MTDL) approach was adopted to ensure synergistic action on multiple drug targets by a single molecule. For this purpose, we designed and synthesized twenty new hybrids consisting of the coumarin nucleus and...

Here, a new two-component hydrogel (CP1OP2-Hgel) was developed, simply by dispersing in water two cationic bactericidal polymers (CP1 and OP2) effective against several multidrug-resistant (MDR) clinical isolates of the most relevant Gram-positive and Gram-negative species. Interestingly, while OP2 acts only as an antibacterial ingredient when...

This work focuses on the clinical‐organizational model implemented in an Italian region (Liguria) to streamline the access procedures to galenic cannabis preparations. The competent local health care authority that takes care of tracing a virtuous path to obtain common, uniform and shared protocols and ensure high standards of care is A.Li.Sa....