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ELGER C. E.

Last name: ELGER C. E.

2006 (v1)

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Exploration of the genetic architecture of idiopathic generalized epilepsies

Hempelmann A. Taylor K. P. Heils A.

Purpose: Idiopathic generalized epilepsy (IGE) accounts for ∼20% of all epilepsies and affects about 0.2% of the general population. The etiology of IGE is genetically determined, but the complex pattern of inheritance suggests an involvement of a large number of susceptibility genes. The objective of the present study was to explore the...

Uploaded on: March 27, 2023
2018 (v1)

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Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Abou-Khalil B. Auce P. Avbersek A.

The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant loci, of which 11 are novel. Using various prioritization criteria, we pinpoint the 21 most...

Uploaded on: April 14, 2023
2012 (v1)

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Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.

Steffens M. Leu C. Ruppert A.

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Uploaded on: April 14, 2023