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Last name: ELIZAROV
First name: Nelli
Institution: UCA
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International audience
By the combination of suitable catalytic methodologies, the synthesis of complex molecules could be performed with limited footprints and energy consumption either in orthogonal multicatalysis, sequential one-pot reactions or sequential reactions in continuous flow. In this account, we present a selection of our recent results in this area of...
Melanoma patients harboring the BRAF V600E mutation are treated with vemurafenib. Almost all of them ultimately acquire resistance, leading to disease progression. Here, we find that a small molecule from a marine sponge, panicein A hydroquinone (PAH), overcomes resistance of BRAF V600E melanoma cells to vemurafenib, leading to tumor...