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ERIKSSON , Urs

Last name: ERIKSSON

First name: Urs

2020 (v1)

Publication

Metadata-only

Cardiomyocyte-Specific JunD Overexpression Increases Infarct Size following Ischemia/Reperfusion Cardiac Injury by Downregulating Sirt3

Akhmedov, Alexander Montecucco, Fabrizio Costantino, Sarah

Ischemia/reperfusion (I/R) injury in acute myocardial infarction activates several deleterious molecular mechanisms. The transcription factor JunD regulates pathways involved in oxidative stress as well as in cellular proliferation, differentiation, and death. The present study investigated the potential role of JunD as a modulator of...

Uploaded on: April 14, 2023
2020 (v1)

Publication

Metadata-only

Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study

Liberale, Luca Gaul, Daniel S Akhmedov, Alexander

AIMS: Aging is an established risk factor for stroke; genes regulating longevity are implicated in the pathogenesis of ischaemic stroke where to date, therapeutic options remain limited. The blood-brain barrier (BBB) is crucially involved in ischaemia/reperfusion (I/R) brain injury thus representing an attractive target for developing novel...

Uploaded on: April 14, 2023