ERRICO S.

Introduction: The assumption of substances in order to increase physical performances is a phenomenon practiced for millennia with the use of a large variety of substances. The growing spread of the abuse of performance-enhancing drugs, once limited to professional athletes, represents a significant public health issue involving multiple...

Methadone is a synthetic opioid, a pure agonist of the μ receptor. It is used for opioid maintenance therapy in heroin addiction. In recent years, Italian studies of incidence and prevalence have indicated an increase in the illegal sales of methadone and, consequently, an increase in deaths due to acute methadone intoxication as well. The...

Decapitation is the severance of the head from the body. Generally, cases of decapitation are considered as homicidal, as there are very few cases of accidental and suicidal decapitation in the world. In homicides, decapitation could be the cause of death as well the result of a postmortem body dismemberment or mutilation in order, for example,...

No description

Many neurodegenerative diseases are associated with the self-assembly of peptides and proteins into fibrillar aggregates. Soluble misfolded oligomers formed during the aggregation process, or released by mature fibrils, play a relevant role in neurodegenerative processes through their interactions with neuronal membranes. However, the...

Trodusquemine is an aminosterol known to prevent the binding of misfolded protein oligomers to cell membranes and to reduce their toxicity in a wide range of neurodegenerative diseases. Its precise mechanism of action, however, remains unclear. To investigate this mechanism, we performed confocal microscopy, fluorescence resonance energy...