FENOGLIO , Daniela

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Background: Clinical Trials (CTs) are indispensable instruments for evidence-based medicine and frequently necessitate the management, sharing and analysis of large amounts of data amongst partners in different locations. Methods: To effectively satisfy these requirements, the proposed solution combines a web platform and a Clinical Data...

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Th17 is a subset of T helper lymphocytes and exerts pro-inflammatory activities. Recently, it has been reported that serum IL-17 levels are high in the most severe patients with birch allergy studied both outside and during the pollen season. This study aims to compare the frequency of peripheral IL-17-producing T cells in children with...

Allergic rhinitis (AR) is characterized by a Th2 polarized immune response, and specific immunotherapy modifies this arrangement, restoring a physiologic Th1 profile. Sublingual immunotherapy (SLIT) is widely prescribed. The aim of the study is to evaluate two different methods for assessing IFN-γ, namely ELISPOT and ELISA, before and after a...

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Cancer vaccines represent a promising therapeutic approach for which prime time is imminent. However, clinical efficacy must be improved in order for cancer vaccines to become a valid alternative or complement to traditional cancer treatments. Considerable efforts have been undertaken so far to better understand the fundamental requirements for...

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Abstract: Nel contesto sanitario, l'utilizzo dell'Information and Communication Technology (ICT) è diventato uno strumento fondamentale. A tale proposito, anche la Commissione Europea si è espressa in tale senso ("eHealth Action Plan 2012-2020 - Innovative healthcare for the 21st century", Brussels, 6.12.2012) evidenziando l'importanza...

Often researchers find it difficult to interpret and correlate the results obtained from several experiments thus the development of a system that would allow storage, display and data analysis would be very useful. A web based interface is presented that allows people from a laboratory to submit the collected data and to compare results within...

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Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Consequently, allergic patients have a defect in IFN-gamma production. So far, however, all the experimental studies have investigated only the IFN-gamma production induced by the causal allergen. The aim of this study is to investigate whether there is a difference in...

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Background:T helper (Th)-17 cells are a subset of T helper lymphocytes thatexert regulatory activities. Recently, it has been reported that serum interleukin(IL)-17 levels are high in the most severe cases of birch allergy studied outsidethe pollen season.Objective:The aim of this study was to investigate a possible relationshipbetween serum...

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In early HIV-1 infection, V delta 1 T lymphocytes are increased in peripheral blood and this is related to chemokine receptor expression, chemokine response, and recirculation. Herein we show that, at variance with healthy donors, in HIV-1-infected patients ex vivo-isolated V delta 1 T cells display cytoplasmic interferon-gamma (IFN-gamma)....