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Last name: FERRO
First name: Margherita
Email: margherita.ferro@unige.it
Institution: UNIGE
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Hepatoma cell cultures as in vitro models for the hepatotoxicity of xenobiotics
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modulation of carcinogen-metabolizing enzymes in cultured hepatoma cells
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Cytotoxic effects related to exposure to benzaldehyde, acetaldehyde, propionaldehyde and valeraldehyde in hepatoma cell lines
Exposure of CHO cells to biotic and xenobiotic aldehydes : DNA-damaging activity
Comparative subcellular distribution of benzaldehyde and acetaldehyde dehydrogenase activities in two hepatoma cell lines and in normal hepatocytes.
cytotoxic effects of different xenobiotics in three hepatoma cell lines, from rat and human
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We thus applied only one prooxidant stimulus after enriching two hepatoma cell lines (MH1C1 and 7777) with lower concentrations of arachidonic acid (ARA) than those used in previous work, but still able to enhance lipid peroxidation without loss of viability. After pretreatment with ARA and exposure to the prooxidant, the cultured cells were...
effects of Methylglyoxal on induction of DNA-protein cross-links and cytotoxicity in Chinese hamster ovary cells
Hepatoma cells show alterations in the response to oxidative stress (decreased lipid peroxidation) and in xenobiotic metabolism enzymes (decreased P450, increased GST and ALDH3). This study examined the effect of lipid peroxidation on the expression of the above enzymes in two rat hepatoma cell lines (MH1C1 and 7777). To induce oxidative...
MH1C1 hepatoma cells exposed to CYP450 inducers, MC and BNF, showed an induction of cytochrome(s) P450-dependent drug metabolism
This study is part of the Multicentric Project (MEIC) on evaluation of the cytotoxicity of the first 20 chemicals under study, in two hepatoma cell lines with different xenobiotic metabolism capacities