FILACI , Gilberto

The CD8+ T suppressor lymphocytes identified in humans belong to three different subpopulations. All of them inhibit the proliferation of antigen-specific T cells. The type 1 and type 2 of CD8+ T suppressor cells are characterized by the CD8+CD28− phenotype, while no detailed data are available at the moment on the phenotype of the type 3 of...

Vaccino peptidico antitumorale

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Cancer vaccines represent a promising therapeutic approach for which prime time is imminent. However, clinical efficacy must be improved in order for cancer vaccines to become a valid alternative or complement to traditional cancer treatments. Considerable efforts have been undertaken so far to better understand the fundamental requirements for...

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There is convincing evidence that soluble HLA-A,-B,-C (sHLA-A,-B,-C) and soluble HLA-G (sHLA-G) antigens can induce apoptosis in CD8(+) activated T cells although there is scanty and conflicting information about the mechanism(s) by which sHLA-A,-B,-C antigens and sHLA-G antigens induce apoptosis. In this study we have compared the...

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A nanoarray or microarray of antibodies comprising a planar surface having an ultraflat surface is described, which is characterized in that it comprises a planar substrate functionalized with a first monolayer of linking molecules, preferably APTES molecules, and a second monolayer of small peptides of the general formula (I) capable of...