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2008 (v1)PublicationUploaded on: April 14, 2023
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2003 (v1)Publication
A new class of cardiotonic agents characterized by a 2-pyridone structure was synthesized. Appropriate sym-2-dimethylaminomethylene-1,3-diones reacted with methylcyanoacetate to afford the desired compounds. These derivatives were evaluated for their ability in inducing cardiotonic response on guinea pig isolated myocardial preparations....
Uploaded on: April 14, 2023 -
2002 (v1)Publication2- substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylates: synthesis and cardiotonic activity
A series of milrinone analogues, namely 2-substituted 5-acetyl-1,6-dihydro-6-oxo-3-pyridinecarboxylates 17-23, related carboxylic acids 24-27 and 6-substituted 3-acetyl 1,2-dihydro-2-pyridones 28 and 29, in which the cyano group was replaced by the acetyl function, was prepared. All the compounds were tested for their effects on contractile...
Uploaded on: March 31, 2023 -
2003 (v1)Publication
Two mechanisms are responsible for the positive inotropic effect of the cardiotonic drug milrinone, i.e., inhibition of type III cAMP phosphodiesterase (PDE III), and displacement of endogenous adenosine from A1 inhibitory receptor. Since PDE III inhibition may increase the likelihood of cardiac arrhythmias by increasing cAMP content, our...
Uploaded on: April 14, 2023