FLORIO , Tullio

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The current treatment of neuroendocrine tumors include the use of somatostatin (SST) agonists. These compounds are able to control most of the symptoms caused by the hypersecretory activity of the tumor cells, and for this reason, they provide a significant improvement in the well-being of the patients. Although, several reports also showed a...

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Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR) represents one of the main intracellular mechanisms involved in the antiproliferative effect of somatostatin (SST) and analogues. Since their molecular cloning, the role of PTPs is emerging as a major regulator of different cell functions including cell...

The pituitary needs high plasticity of the hormone-producing cell compartment to generate the continuously changing hormonal signals that govern the key physiological processes it is involved in, as well as homeostatic cell turnover. However, the underlying mechanisms are still poorly understood. It was proposed that adult stem cells direct the...

Underlying mechanisms leading to pituitary plasticity by which the gland adapts the number of hormone-producing cell to the continuously changing physiological requirements, are still poorly understood. Adult stem cells were shown to direct homeostatic cell maintenance, regeneration and functional plasticity in several organs and tissues. Only...

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Somatostatin (SST), an peptide expressed in most organs and tissues, and controlling a wide range of physiological activities, is also one of the main endogenous regulators of cell proliferation. Thus, it has been proposed its clinical use in the cancer pharmacological therapy, but the outcome of the trials performed has been largely...

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Glioblastoma is the most prevalent and malignant form of brain cancer, but the current available multimodality treatments yield poor survival improvement. Thus, innovative therapeutic strategies represent the challenging topic for glioblastoma management. Multidisciplinary advances, supporting current standard of care therapies and...