Somatostatin (SST), an peptide expressed in most organs and tissues, and controlling a wide range of physiological activities, is also one of the main endogenous regulators of cell proliferation. Thus, it has been proposed its clinical use in the cancer pharmacological therapy, but the outcome of the trials performed has been largely...
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1998 (v1)PublicationUploaded on: March 31, 2023
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2016 (v1)Publication
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Uploaded on: April 14, 2023 -
2010 (v1)Publication
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2014 (v1)Publication
Underlying mechanisms leading to pituitary plasticity by which the gland adapts the number of hormone-producing cell to the continuously changing physiological requirements, are still poorly understood. Adult stem cells were shown to direct homeostatic cell maintenance, regeneration and functional plasticity in several organs and tissues. Only...
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2008 (v1)Publication
The current treatment of neuroendocrine tumors include the use of somatostatin (SST) agonists. These compounds are able to control most of the symptoms caused by the hypersecretory activity of the tumor cells, and for this reason, they provide a significant improvement in the well-being of the patients. Although, several reports also showed a...
Uploaded on: March 25, 2023 -
2012 (v1)Publication
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2008 (v1)Publication
Activation of phosphotyrosine phosphatases (PTPs) by somatostatin receptor (SSTR) represents one of the main intracellular mechanisms involved in the antiproliferative effect of somatostatin (SST) and analogues. Since their molecular cloning, the role of PTPs is emerging as a major regulator of different cell functions including cell...
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2011 (v1)Publication
The pituitary needs high plasticity of the hormone-producing cell compartment to generate the continuously changing hormonal signals that govern the key physiological processes it is involved in, as well as homeostatic cell turnover. However, the underlying mechanisms are still poorly understood. It was proposed that adult stem cells direct the...
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2009 (v1)Publication
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1996 (v1)Publication
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2011 (v1)Publication
Somatostatin (SST) exerts antiproliferative effects in normal and tumor epithelial and endocrine cells through the activation of five G protein-coupled receptors (SSTR15). Somatostatin receptors are expressed in several human tumors, including brain cancer. Multiple intracellular pathways are involved in the antiproliferative effects of SST,...
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2017 (v1)Publication
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Uploaded on: March 27, 2023