January 1998 (v1)
Journal article
ABSTRACT Cell cycle arrest in G 1 in response to ionizing radiation or senescence is believed to be provoked by inactivation of G 1 cyclin-cyclin-dependent kinases (Cdks) by the Cdk inhibitor p21 Cip1/Waf1/Sdi1 . We provide evidence that in addition to exerting negative control of the G 1 /S phase transition, p21 may play a role at the onset of...
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