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FARINELLI , Mélissa

Last name: FARINELLI

First name: Mélissa

June 2024 (v1)

Journal article

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CHCHD10<sup>S59L/+</sup> mouse model: Behavioral and neuropathological features of frontotemporal dementia

Genin, Emmanuelle Di Borgo, Pauline Pozzo Lorivel, Thomas

CHCHD10-related disease causes a spectrum of clinical presentations including mitochondrial myopathy, cardiomyopathy, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). We generated a knock-in mouse model bearing the p.Ser59Leu (S59L) CHCHD10 variant. Chchd10S59L/+ mice have been shown to phenotypically replicate the...

Uploaded on: November 9, 2024
June 2024 (v1)

Journal article

Metadata-only

CHCHD10S59L/+ mouse model: Behavioral and neuropathological features of frontotemporal dementia

Genin, Emmanuelle Di Borgo, Pauline Pozzo Lorivel, Thomas

International audience

Uploaded on: November 9, 2024
November 3, 2020 (v1)

Journal article

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Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

Eysert, Fanny Coulon, Audrey Boscher, Emmanuelle

Although APP metabolism is being intensively investigated, a large fraction of its modulators is yet to be characterized. In this context, we combined two genome-wide high-content screenings to assess the functional impact of miRNAs and genes on APP metabolism and the signaling pathways involved. This approach highlighted the involvement of...

Uploaded on: December 4, 2022