Natural quantitative variation in developmental processes, such as cell proliferation, must be driven by allelic variation. Yet, the genotype-phenotype relationships underlying such trait variation are understudied due to their inherent complexity. Taking advantage of the simple Caenorhabditis elegans germline stem cell system, we used a...
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November 7, 2022 (v1)PublicationUploaded on: December 4, 2022
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May 17, 2023 (v1)Journal article
Abstract To study how natural allelic variation explains quantitative developmental system variation, we characterized natural differences in germ stem cell niche activity, measured as progenitor zone (PZ) size, between two Caenorhabditis elegans isolates. Linkage mapping yielded candidate loci on chromosomes II and V, and we found that the...
Uploaded on: October 24, 2024 -
December 8, 2021 (v1)Journal article
Maintaining reproduction in highly variable, often stressful, environments is an essential challenge for all organisms. Even transient exposure to mild environmental stress may directly damage germ cells or simply tax the physiology of an individual, making it difficult to produce quality gametes. In Caenorhabditis elegans , a large fraction of...
Uploaded on: December 3, 2022 -
April 2019 (v1)Journal article
International audience
Uploaded on: December 4, 2022