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FENG , Weijun

Last name: FENG

First name: Weijun

August 9, 2017 (v1)

Publication

Metadata-only

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

Feng, Weijun Kawauchi, Daisuke Körkel-Qu, Huiqin

Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, is indispensable for normal cerebellar development. Genetic inactivation of Chd7 in cerebellar granule neuron progenitors...

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