FERRARI , Pier Francesco

In the field of tissue engineering, there is an increased demand for small diameter vascular grafts to treat peripheral vascular pathologies and ischemic heart diseases. The limited availability of suitable autogenous veins and the drawbacks related to the use of synthetic materials, such as polyethylene terephthalate (Dacron®) and expanded...

Ischemia/reperfusion (I/R) injury complicates both unpredictable events (myocardial infarction and stroke) as well as surgically-induced ones when transient clampage of major vessels is needed. Although the main cause of damage is attributed to mitochondrial dysfunction and oxidative stress, the use of antioxidant compounds for protection gave...

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Spent coffee grounds are a rich source of antioxidants and caffeine, which recovery and application in cosmetic field could lead to the formulation of healthier and cheaper products. Indeed, this by-product of food industry is available worldwide in huge amount, already in powder form, reducing the pretreatments required before extraction...

During the last decade, great attention has been paid to drug delivery systems that are able to induce a site-specific and tunable release of biomolecules, attenuating the drawbacks of common therapy. The encapsulation of bioactive compounds, such as proteins and drugs, offers the advantage of enhancing the pharmacokinetics and bioavaliability...

This work is a comparative study among three different biocompatible and biodegradable polymers, poly(lactic-co-glycolic acid), poly(epsilon-caprolactone), and poly(lactic acid), used to produce microparticles for the encapsulation of bevacizumab for drug delivery purposes. All the formulations were produced using the double emulsion...

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Atherosclerosis represents one of the main causes of death in the Western world. It is a multifactorial pathology characterized by lesions that reduce the lumen of the vessels causing serious clinical events. The extra-domain B of fibronectin is overexpressed during angiogenesis and in tissues undergoing growth and extensive remodeling, i.e.,...

: The fabrication of biodegradable, bioabsorbable, and biocompatible vascular scaffolds with enhanced mechanical and biological properties that are able to modulate local inflammation and induce endothelialization after surgical implant is still a challenge. In this work, a fibrous scaffold, made of poly(ε-caprolactone) and poly(glycerol...

: Vascular tissue engineering endeavors to design, fabricate, and validate biodegradable and bioabsorbable small-diameter vascular scaffolds engineered with bioactive molecules, capable of meeting the challenges imposed by commercial vascular prostheses. A comprehensive investigation of these engineered scaffolds in bioreactor is deemed...