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FILIPPI I

Last name: FILIPPI I

2010 (v1)

Publication

Metadata-only

2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors.

Dreassi E Zizzari AT Mori M

The main aim of this study was to enhance the soly. of pyrazolo[3,4-d]pyrimidines 1-8 able to strongly inhibit Src and Abl tyrosine kinase phosphorylation in cell-free assays and to significantly reduce leukemic and osteosarcoma cell lines growth, but characterized by very low soly. in aq. media. Their water soly. was improved between 100 and...

Uploaded on: May 11, 2023