FILIPPI M.

Gadolinium-enhanced magnetic resonance imaging (MRI) and measures of brain volume have been extensively applied in large-scale studies to assess disease activity and irreversible tissue damage in multiple sclerosis (MS). Although histopathological studies of MS demonstrated that axonal transection occurs at sites of inflammatory changes, the...

The characteristic feature of multiple sclerosis (MS) pathology is the demyelinated plaque distributed throughout the central nervous system. Although MS is a primary demyelinating disease, acute axonal injury is common in actively demyelinating MS lesions and it is considered one of the major determinants of neurological deficit. Magnetic...

Introduction. Diffusion measurements inside biological tissues provide information about tissue configuration at a microscopic level, which are inaccessible to other magnetic resonance (MR) techniques. Objectives. To quantify, using diffusion tensor imaging (DTI), the damage of lesions and normal-appearing white matter (NAWM) from patients with...

No description