FONTALVA OSTIO , Sara

The primary function of prefoldin is well-established in the cytoplasm, where it serves as a cochaperone, favouring the co-translational folding of actin and tubulin monomers by transferring them to the ATP-dependent class II chaperonin CCT. The canonical form of prefoldin comprises six subunits known as PFDN1, 2, 3, 4, 5, and 6. This complex...

Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions of prefoldin have been described, including a positive contribution to transcription elongation and chromatin dynamics in yeast. Here we show that prefoldin...