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FRANCESCHELLI , Paola

Last name: FRANCESCHELLI

First name: Paola

2018 (v1)

Publication

Metadata-only

Squalene epoxidase as a promising metabolic target in cancer treatment

Cirmena, Gabriella Franceschelli, Paola Isnaldi, Edoardo

Oncogenic alteration of the cholesterol synthesis pathway is a recognized mechanism of metabolic adaptation. In the present review, we focus on squalene epoxidase (SE), one of the two rate-limiting enzymes in cholesterol synthesis, retracing its history since its discovery as an antimycotic target to its description as an emerging metabolic...

Uploaded on: April 14, 2023