FRANGEUL , Lionel

How persistent viral infections are established and maintained is widely debated and remains poorly understood. We found here that the persistence of RNA virus in Drosophila melanogaster was achieved through the combined action of cellular reverse-transcriptase activity and the RNA interference (RNAi) pathway. Fragments of diverse RNA viruses...

Mosquitoes develop long-lasting viral infections without substantial deleterious effects, despite high viral loads. This makes mosquitoes efficient vectors for emerging viral diseases with enormous burden on public health. How mosquitoes resist and/or tolerate these viruses is poorly understood. Here we show that two species of Aedes mosquitoes...