FRIGO , Matteo

The human brain is a complex multiscale biomechanism composed of nearly a hundred billion neurons.Using diffusion magnetic resonance imaging (dMRI), in this thesis we contributed to probing in-vivo the microstructural composition of brain tissues with multi-compartment (MC) models, the trajectories of the axonal pathways connecting different...

International audience

Characterizing the connection between brain structure and brain function is essential for understanding how behaviour emerges from the underlying anatomy. A number of studies have shown that the network structure of the white matter shapes functional connectivity. Therefore, it should be possible to predict, at least partially, functional...

The in vivo validation of diffusion MRI (dMRI)-based tractography has beenshown to be a challenging task [Maier-hein et al.]. Therefore, we have been investigating how 3D Polarized Light Imaging (3D-PLI) could be used as a validation tool for dMRI-based fiber orientation estimation and tractography. PLI is an optical imaging technique that...

The architecture of the white matter is endowed with kissing and crossing bundles configurations. When these white matter tracts are reconstructed using diffusion MRI tractography, this systematically induces the reconstruction of many fiber tracts that are not coherent with the structure of the brain. The question on how to discriminate...

No description