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FROMIGUE , Olivia

Last name: FROMIGUE

First name: Olivia

November 2006 (v1)

Journal article

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RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation

Fromigue, Olivia Hay, Eric Modrowski, Dominique

Osteosarcoma is the most common primary bone tumour in young adults. Despite improved prognosis, resistance to chemotherapy remains responsible for failure of osteosarcoma treatment. The identification of signals that promote apoptosis may provide clues to develop new therapeutic strategies for chemoresistant osteosarcoma. Here, we show that...

Uploaded on: March 26, 2023
July 2011 (v1)

Journal article

Metadata-only

CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis.

Fromigue, Olivia Hamidouche, Zahia Vaudin, Pascal

Osteosarcoma is the most common primary tumor of bone. The rapid development of metastatic lesions and resistance to chemotherapy remain major mechanisms responsible for the failure of treatments and the poor survival rate for patients. We showed previously that the HMGCoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitor statin...

Uploaded on: December 3, 2022