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FRUMENTO , Giulia

Last name: FRUMENTO

First name: Giulia

2021 (v1)

Publication

Metadata-only

Blocking glutamate mGlu5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1G93A mouse model of amyotrophic lateral sclerosis

Milanese, Marco Bonifacino, Tiziana Torazza, Carola

The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although excessive glutamate (Glu) transmission and the downstream cytotoxic cascades are major mechanisms for motor neuron death. Two metabotropic glutamate receptors (mGlu1 and mGlu5) are overexpressed in ALS and regulate cellular disease processes. Expression and...

Uploaded on: March 27, 2023
2023 (v1)

Publication

Metadata-only

Changes at glutamate tripartite synapses in the prefrontal cortex of a new animal model of resilience/vulnerability to acute stress

Bonifacino, Tiziana Mingardi, Jessica Facchinetti, Roberta

Stress represents a main risk factor for psychiatric disorders. Whereas it is known that even a single trauma may induce psychiatric disorders in humans, the mechanisms of vulnerability to acute stressors have been little investigated. In this study, we generated a new animal model of resilience/vulnerability to acute footshock (FS) stress in...

Uploaded on: November 25, 2023