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FUSTERO , Santos

Last name: FUSTERO

First name: Santos

May 18, 2018 (v1)

Publication

Metadata-only

Fluorinated chaperone-ß-cyclodextrin formulations for ß-glucocerebrosidase activity enhancement in neuronopathic Gaucher disease

García Moreno, M. Isabel Mata, Mario de la Sánchez Fernández, Elena Matilde

Amphiphilic glycomimetics encompassing a rigid, undistortable nor-tropane skeleton based on 1,6-anhydro-L-idonojirimycin and a polyfluorinated antenna, when formulated as the corresponding inclusion complexes with β-cyclodextrin (βCD), have been shown to behave as pharmacological chaperones (PCs) that efficiently rescue lysosomal β-...

Uploaded on: March 26, 2023