International audience
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September 2010 (v1)Journal articleUploaded on: December 4, 2022
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March 3, 2015 (v1)Publication
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Uploaded on: December 4, 2022 -
February 15, 2022 (v1)Publication
Set1 is the catalytic subunit and the central component of the evolutionarily conserved Set1 complex (Set1C) that methylates histone 3 lysine 4 (H3K4). Here we have determined protein/protein interactions within the complex and related the substructure to function. The loss of individual Set1C subunits differentially affects Set1 stability,...
Uploaded on: March 25, 2023 -
February 8, 2022 (v1)Publication
Abstract Accumulation of senescent cells has been causally linked to the development of age-related pathologies. Here, we characterized a new mouse model (p21 +/Tert ) whose telomerase (TERT) is expressed from the p21 promoter that can be activated in response to telomere dysfunction. Lung parenchyma from p21 +/Tert old mice accumulated fewer...
Uploaded on: December 3, 2022