G

G. BOTTA

Last name: G. BOTTA

2008 (v1)

Publication

Metadata-only

Cytotoxic effects of a novel pyrazolopyrimidine derivative entrapped in liposomes in anaplastic thyroid cancer cells in vitro and in xenograft tumors in vivo

M. CELANO SCHENONE, SILVIA D. COSCO

In this study, we evaluated the activity of two novel pyrazolopyrimidine derivs. (Si 34 and Si 35) against ARO cells, a human anaplastic thyroid cancer cell line. ARO cells exposed to different concns. of the drugs showed a reduced growth rate and an increase of mortality. After 72 h incubation, doses of 5 and 10 μM Si 34 detd. a decrease of...

Uploaded on: May 13, 2023