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GALANTE , Denise

Last name: GALANTE

First name: Denise

2012 (v1)

Publication

Metadata-only

Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

GALANTE, DENISE CORSARO, ALESSANDRO FLORIO, TULLIO

Among the different species of water-soluble beta-peptides (Abeta1-42, Abeta1-40 and N-terminal truncated Abeta-peptides), Abetapy3-42 is thought to play a relevant role in Alzheimer's pathogenesis due to its abundance, resistance to proteolysis, fast aggregation kinetics, dynamic structure and high neurotoxicity. To evaluate the specific...

Uploaded on: April 14, 2023
2016 (v1)

Publication

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A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

GALANTE, DENISE Ruggeri, Francesco Simone Dietler, Giovanni

A wide consensus based on robust experimental evidence indicates pyroglutamylated amyloid-β isoform (AβpE3-42) as one of the most neurotoxic peptides involved in the onset of Alzheimer's disease. Furthermore, AβpE3-42 co-oligomerized with excess of Aβ1-42, produces oligomers and aggregates that are structurally distinct and far more cytotoxic...

Uploaded on: April 14, 2023
2016 (v1)

Publication

Metadata-only

From Bio-Inspired Molecules to Alzheimer's Disease Prevention

MONI, LISA BANFI, LUCA GALANTE, DENISE

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Uploaded on: April 14, 2023