GANDOGLIA , Ilaria

Neuron/Glial 2 antigen (NG2) is a membrane proteoglycan expressed in many cellular types. In central nervous system (CNS), NG2 is expressed on oligodendrocyte precursor cells and on pericytes. NG2 is involved in cellular adhesion mechanisms, but its role is not completely clear. We showed that in the animal model of multiple sclerosis (MS),...

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Natalizumab (NTZ) is a monoclonal antibody targeting the α4β1 integrin (CD49d/CD29), very late antigen-4 (VLA-4), which is approved for treatment of relapsing-remitting multiple sclerosis (RR-MS). A possible association between NTZ treatment and a higher risk of melanoma is under debate. Natural Killer (NK) cells, which express VLA-4, represent...

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The risk of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab for multiple sclerosis (MS) is a serious concern. The presence of anti-JC virus antibodies is a risk factor for PML development, but 2.5 \% of the patients result falsely-negative, while the prognostic relevance of testing JCV-DNA in biological...