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GIACCHELLO , Ilaria

Last name: GIACCHELLO

First name: Ilaria

March 11, 2019 (v1)

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Synthesis of properly substituted pyridine and pyrimidine derivatives and their biological evaluation as potential antiviral agents

GIACCHELLO, ILARIA

Influenza A viruses (IAVs) belong to the Orthomixoviridae, a family of enveloped viruses with a single-stranded negative-sense and eight-segmented RNA genome. They are the most prevalent pathogens for both humans and animals, causing the so-called seasonal flu and widespread pandemics. A part from the use of vaccines, viral infections can be...

Uploaded on: April 14, 2023
2017 (v1)

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Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors

Musumeci, Francesca Sanna, Monica GRECO, CHIARA

Introduction: Btk is a tyrosine kinase dysregulated in several B-cell malignancies and autoimmune diseases, and this has given rise to a search for Btk inhibitors. Nevertheless, only one Btk inhibitor, ibrutinib, has been approved to date, although other compounds are currently being evaluated in clinical trials or in preclinal stages. Area...

Uploaded on: April 14, 2023
2018 (v1)

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Exploring SAR of a new generation of pyrazolo[3,4-d]pyrimidines as Fyn tyrosine kinase inhibitors

Musumeci, F. GRECO, CHIARA Navarro Pinin, L.

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Uploaded on: April 14, 2023